ASH2L

Across TCGA patient cohorts, ASH2L mutation is significantly associated with the RNA expression of many other genes, with 3,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASH2L-associated genes across cancer lineages are IGHD6-19, IGHD4-4, and RNU6-97P. Each is linked with ASH2L in more than 2 cancer types. Because this analysis shows association rather than direction, both ASH2L-to-partner and partner-to-ASH2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD6-19 grouped by ASH2L-low versus ASH2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASH2L→partner) and Y-score (partner→ASH2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD6-19 →	+0.330	+2.098	.002	.007	3	3
UCEC	IGHD4-4 →	+0.403	+2.525	<.001	.005	3	3
COAD	RNU6-97P →	+0.574	+3.215	.002	.003	3	2
COAD	RNU6-5P →	+0.513	+4.290	.008	<.001	3	2
COAD	MIR769 →	+0.332	+3.843	<.001	<.001	3	2
COAD	LINC02528 →	+0.408	+3.715	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,072 associations by consensus.

IGHD6-19 by ASH2L expression — UCEC

Explore this box plot interactively →