ASH2L

Across TCGA pan-cancer cohorts, ASH2L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ASH2L’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ASH2L RNA is repressed in tumor relative to normal tissue. In most cancer types ASH2L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where ASH2L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASH2L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.215	.002	6	view →
KICH	Female	All	−0.889	<.001	5	view →
LUSC	All	All	+0.431	<.001	5	view →
STAD	All	II,III,IV	+0.317	.024	4	view →
BRCA	All	II,III,IV	+0.225	.027	4	view →
CHOL	Female	All	+1.243	<.001	3	view →
LUAD	Female	II,III,IV	−0.373	<.001	3	view →
UCEC	All	All	−0.388	.023	2	view →
ESCA	All	II,III,IV	−0.325	.019	2	view →
READ	Female	All	−0.660	.040	1	view →
LIHC	All	All	+0.246	.024	1	view →
HNSC	All	All	+0.232	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ASH2L–THCA

Open the THCA breakdown →