ASCL3

Across TCGA patient cohorts, ASCL3 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ASCL3-associated genes across cancer lineages are RN7SL248P, LINC01744, and BNIP3P41. Each is linked with ASCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCL3-to-partner and partner-to-ASCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by ASCL3-low versus ASCL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCL3→partner) and Y-score (partner→ASCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.147	+4.722	<.001	.004	3	2
SKCM	LINC01744 →	+0.026	+5.208	<.001	.001	3	2
COAD	BNIP3P41 →	+0.064	+6.734	<.001	<.001	3	2
LUSC	MIR583 →	+0.591	+5.337	<.001	.006	3	1
LUSC	RPL31P1 →	+0.150	+5.038	<.001	.009	3	1
LUSC	NDUFB4P5 →	+0.126	+5.625	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

RN7SL248P by ASCL3 expression — UCEC

Explore this box plot interactively →