ASCC3

Across TCGA patient cohorts, ASCC3 mutation is significantly associated with the RNA expression of many other genes, with 5,583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASCC3-associated genes across cancer lineages are YARS2, CDT1, and MCM7. Each is linked with ASCC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ASCC3-to-partner and partner-to-ASCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YARS2 grouped by ASCC3-low versus ASCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC3→partner) and Y-score (partner→ASCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YARS2 →	+0.343	+1.617	<.001	<.001	3	5
UCEC	CDT1 →	+0.867	+2.491	<.001	<.001	3	5
BLCA	MCM7 →	+0.584	+3.488	.002	.002	3	4
COAD	GEMIN4 →	+0.714	+3.219	<.001	.009	3	4
UCEC	RFC2 →	+0.425	+1.779	<.001	<.001	3	4
COAD	KIF22 →	+0.460	+3.402	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,583 associations by consensus.

YARS2 by ASCC3 expression — UCEC

Explore this box plot interactively →