ASCC3

Across TCGA cell cohorts, ASCC3 mutation is significantly associated with the RNA expression of many other genes, with 1,588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASCC3-associated genes across cancer lineages are NEUROG1, SEMA3G, and DTWD1. Each is linked with ASCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASCC3-to-partner and partner-to-ASCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROG1 grouped by ASCC3-low versus ASCC3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASCC3→partner) and Y-score (partner→ASCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NEUROG1 →	+0.032	+4.614	<.001	.004	3	2
LARGE_INTESTINE	SEMA3G →	+0.571	+1.706	.004	<.001	3	2
LARGE_INTESTINE	DTWD1 →	+0.606	+2.043	<.001	<.001	3	2
LARGE_INTESTINE	MAPK8 →	+0.702	+2.222	<.001	.001	3	2
LARGE_INTESTINE	CASC3 →	+0.417	+2.584	.002	.001	3	2
LARGE_INTESTINE	PHF12 →	+0.455	+1.837	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,588 associations by consensus.

NEUROG1 by ASCC3 expression — PANCREAS

Explore this box plot interactively →