ASB17

Across TCGA patient cohorts, ASB17 mutation is significantly associated with the RNA expression of many other genes, with 1,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB17-associated genes across cancer lineages are RN7SKP153, RNU6-1009P, and RNU6-416P. Each is linked with ASB17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB17-to-partner and partner-to-ASB17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP153 grouped by ASB17-low versus ASB17-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB17→partner) and Y-score (partner→ASB17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RN7SKP153 →	+0.217	+5.093	<.001	.008	3	2
LGG	RNU6-1009P →	+0.647	+5.392	<.001	.005	3	2
BRCA	RNU6-416P →	+0.268	+4.575	<.001	.009	3	2
SKCM	SNORA58 →	+0.409	+3.432	.007	.009	3	2
UCEC	SLC36A4 →	+1.206	+3.459	<.001	.005	3	2
UCEC	SAPCD2 →	+1.073	+3.491	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,250 associations by consensus.

RN7SKP153 by ASB17 expression — LGG

Explore this box plot interactively →