ASB15

Across TCGA patient cohorts, ASB15 mutation is significantly associated with the RNA expression of many other genes, with 3,910 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB15-associated genes across cancer lineages are NOC2L, PRMT5, and HECTD3. Each is linked with ASB15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASB15-to-partner and partner-to-ASB15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOC2L grouped by ASB15-low versus ASB15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB15→partner) and Y-score (partner→ASB15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOC2L →	+0.430	+1.868	.001	<.001	3	3
UCEC	PRMT5 →	+0.572	+2.711	.003	.003	3	3
UCEC	HECTD3 →	+0.398	+1.595	<.001	.003	3	3
SKCM	YARS1 →	+0.481	+2.102	<.001	<.001	3	3
UCEC	NOL6 →	+0.595	+2.454	<.001	<.001	3	3
UCEC	ATXN2L →	+0.466	+2.126	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,910 associations by consensus.

NOC2L by ASB15 expression — UCEC

Explore this box plot interactively →