ASB15

Across TCGA pan-cancer cohorts, ASB15 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ASB15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ASB15 RNA is repressed in tumor relative to normal tissue. In most cancer types ASB15 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where ASB15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASB15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−2.357	<.001	11	view →
KIRC	Male	All	−1.649	<.001	11	view →
HNSC	Male	All	−1.104	.001	8	view →
KICH	All	II,III,IV	−1.244	<.001	6	view →
THCA	All	II,III,IV	−0.045	.022	3	view →
UCEC	All	IV	+0.045	.012	2	view →
LIHC	Male	All	+0.036	.023	2	view →
PAAD	Female	All	+0.025	.037	2	view →
BRCA	All	IV	+0.025	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ASB15–KIRP

Open the KIRP breakdown →