ASB15

Across TCGA pan-cancer cohorts, ASB15 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ASB15 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher ASB15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ASB15 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SCLC show a favorable association.

KICH, BLCA, and THCA are the cancer types where ASB15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	All	0.359	1.000	<.001	72	view →
BLCA	OS	Median	All	0.599	0.332	<.001	62	view →
THCA	OS	Tertile	All	0.941	1.000	<.001	37	view →
SCLC	DFS	Quartile	All	0.608	0.216	.001	31	view →
MESO	OS	Quartile	IV	0.129	0.715	.001	30	view →
KIRP	DFS	Tertile	All	0.420	0.626	.001	29	view →
SARC	DFS	Quartile	All	0.382	0.684	<.001	18	view →
KIRC	DFS	Median	III,IV	0.517	0.705	.017	16	view →
ESCA	OS	Quartile	III,IV	0.588	0.286	.027	12	view →
CESC	OS	Quartile	III,IV	0.468	0.777	.019	12	view →
STAD	DFS	Median	III,IV	0.354	0.568	.028	6	view →
COAD	OS	Tertile	All	0.439	0.722	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ASB15–KICH (DFS)

Open the KICH breakdown →