ASB15

Across TCGA patient cohorts, ASB15 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB15-associated genes across cancer lineages are p38-MAPK_pT180_Y182, eIF4E, and p27_pT198. Each is linked with ASB15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASB15-to-partner and partner-to-ASB15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ASB15-low versus ASB15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB15→partner) and Y-score (partner→ASB15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.357	-1.362	.017	.034	3	3
UCEC	eIF4E →	+0.169	+3.335	.016	.005	3	2
UCEC	p27_pT198 →	+0.080	+1.584	.025	.009	3	2
UCEC	4E-BP1_pT37_T46 →	-0.271	-2.102	.031	.016	3	2
UCEC	MEK1 →	+0.351	+2.415	.004	.003	3	1
UCEC	p62 Lck ligand →	+0.329	+2.087	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

p38-MAPK_pT180_Y182 by ASB15 expression — UCEC

Explore this box plot interactively →