ASB14

Across TCGA patient cohorts, ASB14 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASB14-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FASN. Each is linked with ASB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB14-to-partner and partner-to-ASB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ASB14-low versus ASB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB14→partner) and Y-score (partner→ASB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.350	-2.736	<.001	<.001	3	1
UCEC	eIF4E →	+0.206	+3.335	.007	.005	3	1
UCEC	FASN →	+0.402	+1.502	.005	.030	3	1
UCEC	FoxM1 →	+0.198	+1.847	.037	.008	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-1.834	.001	.008	3	1
UCEC	JNK2 →	+0.175	+1.502	.016	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by ASB14 expression — UCEC

Explore this box plot interactively →