ASB14

Across TCGA pan-cancer cohorts, ASB14 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ASB14’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ASB14 RNA is repressed in tumor relative to normal tissue. In most cancer types ASB14 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, HNSC, and LUSC are the cancer types where ASB14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASB14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.273	<.001	9	view →
HNSC	Male	All	−0.740	<.001	8	view →
LUSC	Female	II,III,IV	−0.690	<.001	8	view →
LIHC	All	II,III,IV	+0.249	<.001	8	view →
LUAD	Female	III,IV	−0.521	<.001	7	view →
BRCA	All	III,IV	−0.467	.002	6	view →
CHOL	Male	All	+0.605	<.001	5	view →
UCEC	All	All	−0.221	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ASB14–THCA

Open the THCA breakdown →