ASB14

Across TCGA cell cohorts, ASB14 mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASB14-associated genes across cancer lineages are ETP-45835, Sabutoclax, and Pevonedistat. Each is linked with ASB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASB14-to-partner and partner-to-ASB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETP-45835 grouped by ASB14-low versus ASB14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASB14→partner) and Y-score (partner→ASB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETP-45835 →	+0.259	+2.874	.023	.021	3	1
LARGE_INTESTINE	Sabutoclax →	+0.518	+2.991	.009	.018	2	1
LARGE_INTESTINE	Pevonedistat →	+0.721	+2.649	.036	.046	1	1
LARGE_INTESTINE	Eg5_9814 →	+0.615	+2.807	.025	.045	1	1
LARGE_INTESTINE	IRAK4_4710 →	+0.431	+2.871	.011	.021	1	1
LARGE_INTESTINE	JAK1_8709 →	+0.506	+2.871	.006	.021	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ETP-45835 by ASB14 expression — LARGE_INTESTINE

Explore this box plot interactively →