ARVCF

Across TCGA patient cohorts, ARVCF mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARVCF-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with ARVCF in more than 3 cancer types. Because this analysis shows association rather than direction, both ARVCF-to-partner and partner-to-ARVCF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ARVCF-low versus ARVCF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARVCF→partner) and Y-score (partner→ARVCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.697	-2.263	<.001	<.001	3	4
UCEC	eEF2 →	+0.311	+1.652	.008	.006	3	2
UCEC	eIF4E →	+0.237	+2.263	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.136	-1.906	<.001	.015	3	2
UCEC	FOXO3a_pS318_S321 →	-0.113	-1.584	.005	.032	3	2
UCEC	GAPDH →	+0.527	+2.247	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by ARVCF expression — UCEC

Explore this box plot interactively →