ARVCF

Across TCGA cell cohorts, ARVCF mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARVCF-associated genes across cancer lineages are EIF3L, GATAD2B, and KCNA6. Each is linked with ARVCF in more than 1 cancer types. Because this analysis shows association rather than direction, both ARVCF-to-partner and partner-to-ARVCF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by ARVCF-low versus ARVCF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARVCF→partner) and Y-score (partner→ARVCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.552	+3.364	.002	.002	3	2
BLOOD_Leukemia	GATAD2B →	+0.626	+3.199	.003	.007	3	2
OVARY	KCNA6 →	+0.009	+3.700	<.001	.005	3	2
LARGE_INTESTINE	PROKR1 →	+0.034	+2.310	.004	.006	3	2
LUNG_SCLC	DEFB132 →	+0.019	+5.029	<.001	.006	3	1
KIDNEY	SPACA1 →	+0.060	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

EIF3L by ARVCF expression — LARGE_INTESTINE

Explore this box plot interactively →