ARPC3

Across TCGA patient cohorts, ARPC3 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPC3-associated genes across cancer lineages are RNA5SP407, MIR6793, and RNU6-259P. Each is linked with ARPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPC3-to-partner and partner-to-ARPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP407 grouped by ARPC3-low versus ARPC3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPC3→partner) and Y-score (partner→ARPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP407 →	+0.633	+7.924	<.001	.008	3	2
UCEC	MIR6793 →	+0.773	+2.969	.005	.006	3	1
LUSC	RNU6-259P →	+0.391	+7.924	<.001	.008	3	1
LUSC	RNA5SP487 →	+0.267	+7.924	<.001	.008	3	1
LUSC	RNA5SP518 →	+0.358	+7.924	<.001	.008	3	1
LUSC	RNU6-1270P →	+0.388	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RNA5SP407 by ARPC3 expression — LUSC

Explore this box plot interactively →