ARPC3

Across TCGA pan-cancer cohorts, ARPC3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ARPC3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARPC3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARPC3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, KIRP, and BLCA are the cancer types where ARPC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARPC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.828	<.001	12	view →
KIRP	Male	III,IV	+1.067	<.001	11	view →
BLCA	Male	All	+1.002	<.001	11	view →
HNSC	All	III,IV	+0.481	<.001	11	view →
LIHC	Female	II,III,IV	+1.116	<.001	9	view →
THCA	Female	II,III,IV	+0.577	<.001	9	view →
BRCA	All	III,IV	+0.959	<.001	6	view →
UCEC	All	All	+0.564	<.001	6	view →
CHOL	Male	All	+1.839	<.001	5	view →
KICH	All	All	−0.479	.001	4	view →
STAD	All	All	+0.450	.003	4	view →
LUAD	All	All	+0.189	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ARPC3–KIRC

Open the KIRC breakdown →