ARPC1A

Across TCGA patient cohorts, ARPC1A mutation is significantly associated with the RNA expression of many other genes, with 979 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPC1A-associated genes across cancer lineages are COPRS, MTDHP2, and RNA5SP432. Each is linked with ARPC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPC1A-to-partner and partner-to-ARPC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPRS grouped by ARPC1A-low versus ARPC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPC1A→partner) and Y-score (partner→ARPC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPRS →	+0.389	+3.595	.004	.001	3	2
CESC	MTDHP2 →	+0.070	+5.196	<.001	.001	3	2
CESC	RNA5SP432 →	+0.405	+6.124	<.001	<.001	3	2
UCEC	RN7SL478P →	+0.174	+1.617	.002	.008	3	2
BLCA	TRDV2 →	+0.166	+4.758	<.001	.003	3	2
UCEC	RETREG3 →	+0.386	+2.891	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 979 associations by consensus.

COPRS by ARPC1A expression — UCEC

Explore this box plot interactively →