ARPC1A

Across TCGA pan-cancer cohorts, ARPC1A RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ARPC1A data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ARPC1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARPC1A expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

KICH, ACC, and LIHC are the cancer types where ARPC1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.670	0.977	<.001	104	view →
ACC	DFS	Median	All	0.284	0.638	<.001	71	view →
LIHC	DFS	Median	All	0.462	0.618	<.001	58	view →
CESC	OS	Quartile	II,III,IV	0.706	0.953	.002	56	view →
KIRP	DFS	Median	All	0.361	0.691	<.001	55	view →
HNSC	DFS	Tertile	III,IV	0.301	0.557	.001	41	view →
LGG	OS	Median	All	0.747	0.874	<.001	38	view →
LUAD	DFS	Median	All	0.607	0.726	<.001	31	view →
UCS	DFS	Tertile	IV	0.237	0.857	.024	24	view →
MESO	DFS	Tertile	All	0.270	0.657	.012	24	view →
SCLC	OS	Median	III,IV	0.292	0.555	.012	22	view →
PAAD	DFS	Quartile	All	0.163	0.503	<.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ARPC1A–KICH (DFS)

Open the KICH breakdown →