ARPC1A

Across TCGA pan-cancer cohorts, ARPC1A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARPC1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARPC1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARPC1A is over-expressed in tumor.

HNSC, KIRC, and KIRP are the cancer types where ARPC1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARPC1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.111	<.001	12	view →
KIRC	Male	IV	+0.874	<.001	12	view →
KIRP	All	II,III,IV	+0.920	<.001	11	view →
COAD	Female	II,III,IV	+0.432	<.001	10	view →
LIHC	Female	II,III,IV	+1.339	<.001	9	view →
LUAD	Male	II,III,IV	+0.813	<.001	9	view →
LUSC	Female	All	+1.059	<.001	8	view →
BLCA	All	All	+0.508	.001	7	view →
KICH	Male	IV	+1.443	.001	6	view →
BRCA	All	II,III,IV	+0.254	<.001	6	view →
CHOL	Male	All	+2.036	<.001	3	view →
ESCA	All	All	+1.198	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARPC1A–HNSC

Open the HNSC breakdown →