ARPC1A

Across TCGA patient cohorts, ARPC1A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARPC1A-associated genes across cancer lineages are MEK1, 14-3-3_beta, and ERK2. Each is linked with ARPC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARPC1A-to-partner and partner-to-ARPC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ARPC1A-low versus ARPC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARPC1A→partner) and Y-score (partner→ARPC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.352	+4.087	.019	<.001	3	2
UCEC	14-3-3_beta →	-0.100	-1.794	.016	.027	3	1
UCEC	ERK2 →	+0.166	+2.000	.037	.030	3	1
UCEC	FOXO3a_pS318_S321 →	+0.121	+2.009	.019	.017	3	1
UCEC	IGFBP2 →	-0.828	-3.169	.001	.018	3	1
UCEC	MSH2 →	-0.235	-2.295	.013	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by ARPC1A expression — UCEC

Explore this box plot interactively →