ARL5B

Across TCGA patient cohorts, ARL5B mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL5B-associated genes across cancer lineages are eEF2, eIF4E, and eIF4G. Each is linked with ARL5B in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL5B-to-partner and partner-to-ARL5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ARL5B-low versus ARL5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL5B→partner) and Y-score (partner→ARL5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.352	+2.459	.007	.018	3	1
UCEC	eIF4E →	+0.176	+3.335	.023	.005	3	1
UCEC	eIF4G →	+0.369	+2.736	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.146	-3.906	<.001	<.001	3	1
UCEC	ERK2 →	+0.176	+1.847	.012	.008	3	1
UCEC	FOXO3a_pS318_S321 →	-0.115	-1.502	.012	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by ARL5B expression — UCEC

Explore this box plot interactively →