ARL5B

Across TCGA pan-cancer cohorts, ARL5B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ARL5B data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ARL5B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARL5B expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

ACC, KIRC, and LUSC are the cancer types where ARL5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.357	0.801	<.001	109	view →
KIRC	DFS	Median	All	0.871	0.715	<.001	56	view →
LUSC	OS	Median	II,III,IV	0.808	0.655	<.001	45	view →
LIHC	OS	Median	All	0.408	0.610	<.001	45	view →
SARC	OS	Median	All	0.647	0.839	<.001	37	view →
LGG	DFS	Median	All	0.811	0.652	<.001	37	view →
UVM	DFS	Tertile	III,IV	0.241	0.780	.006	30	view →
SKCM	OS	Quartile	All	0.379	0.251	.002	30	view →
KIRP	DFS	Quartile	III,IV	0.527	0.957	<.001	25	view →
LAML	DFS	Tertile	All	0.501	0.246	.014	24	view →
KICH	DFS	Median	II,III,IV	0.552	0.922	.003	16	view →
UCEC	OS	Median	IV	0.721	0.253	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ARL5B–ACC (DFS)

Open the ACC breakdown →