ARL5B

Across TCGA pan-cancer cohorts, ARL5B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARL5B’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where ARL5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARL5B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

STAD, KIRP, and KICH are the cancer types where ARL5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARL5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+1.033	<.001	8	view →
KIRP	All	II,III,IV	+0.602	.016	8	view →
KICH	Female	All	−1.113	<.001	5	view →
COAD	Male	All	+0.769	<.001	5	view →
HNSC	All	All	+0.468	.007	5	view →
UCEC	All	II,III,IV	+0.667	.033	4	view →
KIRC	All	All	+0.317	.001	4	view →
BRCA	All	II,III,IV	+0.235	.012	4	view →
ESCA	All	All	+1.186	.001	3	view →
LUSC	All	All	+0.401	.002	3	view →
THCA	All	All	−0.339	.004	2	view →
READ	All	All	+0.490	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARL5B–STAD

Open the STAD breakdown →