ARL10

Across TCGA patient cohorts, ARL10 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARL10-associated genes across cancer lineages are p70-S6K, AMPK_pT172, and Annexin-1. Each is linked with ARL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARL10-to-partner and partner-to-ARL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by ARL10-low versus ARL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARL10→partner) and Y-score (partner→ARL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.204	+2.196	.043	.034	3	1
UCEC	AMPK_pT172 →	+0.440	+3.335	.041	.005	3	1
UCEC	Annexin-1 →	+0.621	+2.827	.024	.035	3	1
UCEC	XBP1 →	-0.211	-2.986	.004	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.665	+2.827	.032	.035	3	1
UCEC	ERK2 →	+0.215	+3.000	.033	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

p70-S6K by ARL10 expression — UCEC

Explore this box plot interactively →