ARID4A

Across TCGA patient cohorts, ARID4A mutation is significantly associated with the RNA expression of many other genes, with 3,764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARID4A-associated genes across cancer lineages are C1QBP, ZPR1, and LINC02241. Each is linked with ARID4A in more than 3 cancer types. Because this analysis shows association rather than direction, both ARID4A-to-partner and partner-to-ARID4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by ARID4A-low versus ARID4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID4A→partner) and Y-score (partner→ARID4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1QBP →	+0.518	+2.364	<.001	<.001	3	4
SKCM	ZPR1 →	+0.665	+3.221	<.001	.009	3	3
LUAD	LINC02241 →	+0.850	+4.022	.009	.001	3	3
UCEC	DNAJC17 →	+0.266	+1.723	.001	<.001	3	3
UCEC	NUP88 →	+0.256	+1.617	.008	.005	3	3
UCEC	RMC1 →	+0.259	+2.353	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

C1QBP by ARID4A expression — UCEC

Explore this box plot interactively →