ARID4A

Across TCGA pan-cancer cohorts, ARID4A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ARID4A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ARID4A RNA is repressed in tumor relative to normal tissue. In most cancer types ARID4A is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and KICH are the cancer types where ARID4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARID4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−0.851	<.001	8	view →
LUAD	Female	II,III,IV	−0.793	<.001	7	view →
KICH	Female	All	−1.020	<.001	6	view →
UCEC	All	All	−0.838	<.001	6	view →
THCA	All	All	−0.437	<.001	6	view →
BRCA	Female	All	−0.423	<.001	6	view →
COAD	Female	All	−0.623	.003	4	view →
HNSC	Female	III,IV	+0.662	.021	1	view →
STAD	All	IV	+0.419	.030	1	view →
KIRP	Male	All	−0.280	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ARID4A–LUSC

Open the LUSC breakdown →