ARID1B

Across TCGA patient cohorts, ARID1B mutation is significantly associated with the RNA expression of many other genes, with 7,337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARID1B-associated genes across cancer lineages are CHEK1, NCAPD3, and DONSON. Each is linked with ARID1B in more than 4 cancer types. Because this analysis shows association rather than direction, both ARID1B-to-partner and partner-to-ARID1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by ARID1B-low versus ARID1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1B→partner) and Y-score (partner→ARID1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.515	+1.673	<.001	.003	3	5
UCEC	NCAPD3 →	+0.598	+1.974	<.001	<.001	3	5
UCEC	DONSON →	+0.471	+1.469	<.001	<.001	3	5
COAD	COX11 →	+0.444	+2.415	<.001	.003	3	5
UCEC	CDT1 →	+0.681	+1.820	<.001	<.001	3	5
UCEC	PDE12 →	+0.475	+1.799	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,337 associations by consensus.

CHEK1 by ARID1B expression — UCEC

Explore this box plot interactively →