ARID1B

Across TCGA pan-cancer cohorts, ARID1B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ARID1B data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher ARID1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated ARID1B expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

SCLC, OV, and KIRC are the cancer types where ARID1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.784	0.493	<.001	96	view →
OV	OS	Tertile	III,IV	0.257	0.408	<.001	88	view →
KIRC	OS	Median	All	0.723	0.552	<.001	85	view →
HNSC	DFS	Quartile	All	0.707	0.490	<.001	51	view →
ACC	DFS	Median	All	0.400	0.759	<.001	48	view →
BRCA	OS	Tertile	All	0.462	0.698	.002	32	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
SARC	OS	Median	All	0.444	0.753	<.001	22	view →
GBM	DFS	Median	All	0.389	0.182	.001	20	view →
LIHC	OS	Tertile	All	0.711	0.826	.015	10	view →
PRAD	DFS	Tertile	All	0.969	0.922	.010	10	view →
DLBC	DFS	Quartile	All	0.676	1.000	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ARID1B–SCLC (OS)

Open the SCLC breakdown →