ARID1B

Across TCGA pan-cancer cohorts, ARID1B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARID1B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ARID1B RNA is repressed in tumor relative to normal tissue. In most cancer types ARID1B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where ARID1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARID1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.766	<.001	8	view →
KICH	Female	All	−1.011	<.001	7	view →
KIRC	Male	II,III,IV	−0.469	<.001	7	view →
COAD	All	All	+0.260	.002	6	view →
CHOL	Male	All	+1.876	<.001	5	view →
LIHC	All	All	+0.364	.001	5	view →
READ	All	III,IV	+0.714	.038	2	view →
STAD	Male	II,III,IV	+0.688	.009	2	view →
KIRP	Male	All	−0.460	.004	2	view →
HNSC	All	All	+0.271	.031	2	view →
BRCA	Female	All	−0.188	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARID1B–THCA

Open the THCA breakdown →