ARID1B

Across TCGA patient cohorts, ARID1B mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARID1B-associated genes across cancer lineages are STAT3_pY705, NF2, and eEF2. Each is linked with ARID1B in more than 4 cancer types. Because this analysis shows association rather than direction, both ARID1B-to-partner and partner-to-ARID1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ARID1B-low versus ARID1B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1B→partner) and Y-score (partner→ARID1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STAT3_pY705 →	-0.325	-3.000	.037	.038	2	5
BRCA	NF2 →	+0.339	+3.006	.001	.020	3	4
COAD	eEF2 →	+0.378	+3.321	.001	.009	2	5
COAD	eIF4E →	+0.262	+3.459	<.001	.004	3	4
COAD	PCNA →	+0.428	+3.915	<.001	<.001	3	4
UCEC	TFRC →	+0.297	+1.807	.049	.024	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

STAT3_pY705 by ARID1B expression — BRCA

Explore this box plot interactively →