ARID1B

Across TCGA cell cohorts, ARID1B mutation is significantly associated with the RNA expression of many other genes, with 808 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARID1B-associated genes across cancer lineages are SPATA19, PPM1M, and H2AZ1. Each is linked with ARID1B in more than 2 cancer types. Because this analysis shows association rather than direction, both ARID1B-to-partner and partner-to-ARID1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA19 grouped by ARID1B-low versus ARID1B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARID1B→partner) and Y-score (partner→ARID1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPATA19 →	+0.115	+3.099	<.001	.002	3	3
BLOOD_Leukemia	PPM1M →	+0.958	+3.120	.001	.009	3	3
STOMACH	H2AZ1 →	+0.862	+3.070	.001	.008	3	3
KIDNEY	HSD3B2 →	+0.090	+3.700	<.001	.006	3	2
SKIN	RD3L →	+0.017	+2.882	<.001	.005	3	2
SKIN	PRSS48 →	+0.041	+2.933	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 808 associations by consensus.

SPATA19 by ARID1B expression — SKIN

Explore this box plot interactively →