ARHGEF40

Across TCGA patient cohorts, ARHGEF40 mutation is significantly associated with the RNA expression of many other genes, with 4,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF40-associated genes across cancer lineages are TAF13, ARHGAP11A, and ZWINT. Each is linked with ARHGEF40 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGEF40-to-partner and partner-to-ARHGEF40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF13 grouped by ARHGEF40-low versus ARHGEF40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF40→partner) and Y-score (partner→ARHGEF40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF13 →	+0.493	+2.593	.001	<.001	3	4
UCEC	ARHGAP11A →	+0.560	+1.999	.001	.002	3	4
UCEC	ZWINT →	+0.646	+2.273	<.001	<.001	3	4
LIHC	RN7SL66P →	+0.116	+4.758	<.001	.006	3	3
UCEC	DLAT →	+0.513	+2.534	<.001	<.001	3	3
UCEC	NUS1 →	+0.429	+2.606	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

TAF13 by ARHGEF40 expression — UCEC

Explore this box plot interactively →