ARHGEF40

Across TCGA patient cohorts, ARHGEF40 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF40-associated genes across cancer lineages are c-Met_pY1235, eIF4E, and mTOR_pS2448. Each is linked with ARHGEF40 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF40-to-partner and partner-to-ARHGEF40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by ARHGEF40-low versus ARHGEF40-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF40→partner) and Y-score (partner→ARHGEF40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	c-Met_pY1235 →	+0.158	+2.824	<.001	.034	3	3
UCEC	eIF4E →	+0.150	+2.598	.028	.005	3	2
UCEC	mTOR_pS2448 →	-0.131	-1.716	.006	.003	3	2
UCEC	P-Cadherin →	-0.113	-2.115	.015	.016	3	2
UCEC	PCNA →	+0.260	+2.321	<.001	<.001	3	2
UCEC	ATM →	-0.473	-3.794	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

c-Met_pY1235 by ARHGEF40 expression — COAD

Explore this box plot interactively →