ARHGEF40

Across TCGA cell cohorts, ARHGEF40 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,065 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF40-associated GO terms across cancer lineages are Positive regulation of supramolecular fiber organization, Actin filament depolymerization, and Regulation of cell-substrate junction organization. Each is linked with ARHGEF40 in more than 13 cancer types. Because this analysis shows association rather than direction, both ARHGEF40-to-partner and partner-to-ARHGEF40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of supramolecular fiber organization grouped by ARHGEF40-low versus ARHGEF40-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF40→partner) and Y-score (partner→ARHGEF40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of supramolecular fiber organization →	+0.111	+1.749	<.001	<.001	3	14
CNS	Actin filament depolymerization →	+0.204	+1.625	<.001	<.001	3	13
STOMACH	Regulation of cell-substrate junction organization →	+0.121	+2.641	<.001	<.001	3	13
BREAST	Regulation of cell-matrix adhesion →	+0.095	+1.636	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Response to oscillatory fluid shear stress →	+0.173	+1.618	.005	.001	2	13
LUNG_NSCLC_LUSC	Cellular response to oscillatory fluid shear stress →	+0.173	+1.618	.005	.001	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,065 associations by consensus.

Positive regulation of supramolecular fiber organization by ARHGEF40 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →