ARHGEF35-AS1

Across TCGA patient cohorts, ARHGEF35-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,217 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ARHGEF35-AS1-associated proteins across cancer lineages are ARHGEF5, ARHGEF35, and ARHGEF5_S1126. Each is linked with ARHGEF35-AS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARHGEF35-AS1-to-partner and partner-to-ARHGEF35-AS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF35-AS1 versus ARHGEF5 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF35-AS1→partner) and Y-score (partner→ARHGEF35-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGEF5 →	+0.428	+0.860	<.001	<.001	3	6
CCRCC	ARHGEF35 →	+0.453	+0.664	<.001	.001	3	4
LSCC	ARHGEF5_S1126 →	+0.985	+0.905	<.001	<.001	3	4
OV	CDK5 →	+0.357	+0.422	.004	.002	3	4
OV	ARHGEF35_S184 →	+1.294	+0.649	<.001	<.001	3	3
BRCA	SEPTIN1_S315 →	-0.742	-0.442	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,217 associations by consensus.

ARHGEF35-AS1 vs ARHGEF5 — LSCC

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