ARHGEF35-AS1

Across TCGA pan-cancer cohorts, ARHGEF35-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARHGEF35-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ARHGEF35-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGEF35-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and KICH are the cancer types where ARHGEF35-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF35-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.412	<.001	11	view →
HNSC	All	II,III,IV	+0.434	<.001	11	view →
KICH	Male	All	−0.820	<.001	8	view →
KIRC	All	II,III,IV	−0.399	<.001	7	view →
BLCA	All	III,IV	+0.437	.001	6	view →
BRCA	Female	All	−0.319	<.001	6	view →
LUSC	All	All	+0.407	<.001	4	view →
CHOL	All	All	+0.384	<.001	4	view →
LIHC	All	All	+0.187	<.001	4	view →
PRAD	All	All	+0.161	.003	2	view →
STAD	All	II,III,IV	+0.168	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARHGEF35-AS1–THCA

Open the THCA breakdown →