ARHGEF35-AS1

Across TCGA pan-cancer cohorts, ARHGEF35-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ARHGEF35-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ARHGEF35-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ARHGEF35-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

LUAD, OV, and READ are the cancer types where ARHGEF35-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.840	0.383	<.001	54	view →
OV	DFS	Tertile	All	0.572	0.453	.004	32	view →
READ	DFS	Median	II,III,IV	0.228	0.771	<.001	31	view →
LGG	OS	Quartile	All	0.720	0.873	.001	27	view →
LUSC	OS	Median	II,III,IV	0.507	0.325	.004	26	view →
UVM	DFS	Tertile	All	0.773	0.389	.007	25	view →
UCEC	DFS	Median	All	0.584	0.709	.003	24	view →
DLBC	DFS	Tertile	All	0.494	0.945	<.001	22	view →
COAD	DFS	Median	All	0.737	0.827	.005	20	view →
BRCA	OS	Median	III,IV	0.878	0.777	.016	20	view →
UCS	OS	Median	II,III,IV	0.784	0.438	.007	18	view →
PAAD	DFS	Quartile	II,III,IV	0.581	0.393	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ARHGEF35-AS1–LUAD (OS)

Open the LUAD breakdown →