ARHGEF25

Across TCGA patient cohorts, ARHGEF25 protein abundance is significantly associated with the protein abundance of many other proteins, with 12,266 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF25-associated proteins across cancer lineages are IRAG1, PPP1R14A, and PRKG1. Each is linked with ARHGEF25 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARHGEF25-to-partner and partner-to-ARHGEF25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF25 versus IRAG1 in UCEC, with a Pearson correlation of 0.51.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF25→partner) and Y-score (partner→ARHGEF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRAG1 →	+0.594	+0.596	<.001	<.001	3	5
COAD	PPP1R14A →	+1.417	+0.868	<.001	<.001	3	5
COAD	PRKG1 →	+0.801	+0.783	<.001	<.001	2	6
COAD	SORBS1 →	+0.929	+0.495	<.001	<.001	3	5
COAD	SPON1 →	+0.976	+0.750	<.001	<.001	3	5
PDAC	SSC5D →	+0.752	+0.636	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,266 associations by consensus.

ARHGEF25 vs IRAG1 — UCEC

Explore this scatter interactively →