ARHGEF25

Across TCGA patient cohorts, ARHGEF25 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGEF25-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and INPP4B. Each is linked with ARHGEF25 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF25-to-partner and partner-to-ARHGEF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ARHGEF25-low versus ARHGEF25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF25→partner) and Y-score (partner→ARHGEF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+2.713	.004	.003	3	2
UCEC	A-Raf_pS299 →	-0.131	-2.000	.001	.009	3	2
UCEC	INPP4B →	-0.291	-2.906	.007	.001	3	2
UCEC	MEK1 →	+0.341	+2.321	.005	<.001	3	2
UCEC	PCNA →	+0.297	+2.201	<.001	<.001	3	2
UCEC	Rab25 →	-0.400	-2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by ARHGEF25 expression — UCEC

Explore this box plot interactively →