ARHGEF25

Across TCGA cell cohorts, ARHGEF25 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGEF25-associated genes across cancer lineages are LIPF, ARRDC5, and OR1D4. Each is linked with ARHGEF25 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGEF25-to-partner and partner-to-ARHGEF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIPF grouped by ARHGEF25-low versus ARHGEF25-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF25→partner) and Y-score (partner→ARHGEF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LIPF →	+0.038	+4.882	.003	<.001	3	3
LUNG_SCLC	ARRDC5 →	+0.085	+3.898	<.001	.005	3	1
LUNG_SCLC	OR1D4 →	+0.028	+4.058	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KCNA4 →	+0.028	+4.371	<.001	.005	3	1
CNS	OR5M8 →	+0.022	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

LIPF by ARHGEF25 expression — SKIN

Explore this box plot interactively →