ARHGDIA

Across TCGA patient cohorts, ARHGDIA mutation is significantly associated with the RNA expression of many other genes, with 263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGDIA-associated genes across cancer lineages are CYCSP49, RN7SL712P, and MIR4510. Each is linked with ARHGDIA in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGDIA-to-partner and partner-to-ARHGDIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP49 grouped by ARHGDIA-low versus ARHGDIA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGDIA→partner) and Y-score (partner→ARHGDIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CYCSP49 →	+0.496	+3.527	<.001	.007	3	2
HNSC	RN7SL712P →	+0.216	+6.008	<.001	.002	3	2
CESC	MIR4510 →	+0.300	+5.342	<.001	.002	3	2
UCEC	ANAPC15P1 →	+0.178	+2.283	.001	.005	3	2
UCEC	RNU7-188P →	+0.284	+4.010	<.001	.007	3	2
CESC	IGHD6-13 →	+1.461	+4.816	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 263 associations by consensus.

CYCSP49 by ARHGDIA expression — BLCA

Explore this box plot interactively →