ARHGDIA

Across TCGA pan-cancer cohorts, ARHGDIA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARHGDIA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARHGDIA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARHGDIA is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where ARHGDIA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGDIA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.847	<.001	12	view →
KIRP	All	II,III,IV	+0.726	<.001	11	view →
KIRC	Female	All	+0.604	<.001	10	view →
LIHC	Female	II,III,IV	+0.799	<.001	9	view →
STAD	Male	II,III,IV	+0.739	<.001	6	view →
KICH	Female	All	−0.736	<.001	6	view →
BRCA	All	III,IV	+0.567	<.001	6	view →
CHOL	Male	All	+1.588	<.001	5	view →
BLCA	Female	III,IV	+0.395	.043	3	view →
ESCA	All	All	+0.992	.006	2	view →
PRAD	All	All	+0.336	.002	2	view →
COAD	Male	IV	+0.378	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARHGDIA–HNSC

Open the HNSC breakdown →