ARHGAP18

Across TCGA patient cohorts, ARHGAP18 mutation is significantly associated with the RNA expression of many other genes, with 3,493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP18-associated genes across cancer lineages are H3P20, RNU4-58P, and TRAJ21. Each is linked with ARHGAP18 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP18-to-partner and partner-to-ARHGAP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P20 grouped by ARHGAP18-low versus ARHGAP18-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP18→partner) and Y-score (partner→ARHGAP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	H3P20 →	+0.142	+5.368	.003	.005	3	3
UCEC	RNU4-58P →	+0.164	+2.396	.001	.001	3	3
BLCA	TRAJ21 →	+0.602	+4.497	<.001	.009	3	3
READ	OR6K5P →	+0.057	+6.257	<.001	.001	3	2
HNSC	KRTAP27-1 →	+0.093	+5.368	<.001	.005	3	2
HNSC	MIR516A1 →	+0.573	+5.303	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,493 associations by consensus.

H3P20 by ARHGAP18 expression — HNSC

Explore this box plot interactively →