ARHGAP18

Across TCGA pan-cancer cohorts, ARHGAP18 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARHGAP18’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ARHGAP18 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGAP18 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and KIRP are the cancer types where ARHGAP18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGAP18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−2.381	<.001	8	view →
LUAD	Female	III,IV	−1.537	<.001	8	view →
KIRP	Male	All	−0.863	<.001	7	view →
KIRC	All	II,III,IV	−0.476	<.001	7	view →
LIHC	Female	II,III,IV	+1.171	<.001	6	view →
STAD	Male	All	+1.046	<.001	6	view →
CHOL	All	All	+2.301	<.001	5	view →
THCA	Male	All	+0.574	<.001	4	view →
UCEC	All	All	−1.006	.001	2	view →
BLCA	All	IV	+0.811	.008	2	view →
COAD	Male	All	+0.614	.002	2	view →
PRAD	All	All	+0.312	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARHGAP18–LUSC

Open the LUSC breakdown →