ARG1

Across TCGA patient cohorts, ARG1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARG1-associated genes across cancer lineages are MEK1, mTOR_pS2448, and p27_pT157. Each is linked with ARG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARG1-to-partner and partner-to-ARG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ARG1-low versus ARG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARG1→partner) and Y-score (partner→ARG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.379	+2.999	.032	.035	3	1
UCEC	mTOR_pS2448 →	-0.190	-3.150	.008	.019	3	1
UCEC	p27_pT157 →	-0.058	-2.986	.038	.035	3	1
UCEC	p27_pT198 →	+0.129	+2.459	.012	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.492	-2.446	.023	.020	3	1
UCEC	PCNA →	+0.238	+3.584	.022	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by ARG1 expression — UCEC

Explore this box plot interactively →