ARAP3

Across TCGA cell cohorts, ARAP3 mutation is significantly associated with the RNA expression of many other genes, with 466 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARAP3-associated genes across cancer lineages are SCN10A, C1orf146, and DPH1. Each is linked with ARAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARAP3-to-partner and partner-to-ARAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN10A grouped by ARAP3-low versus ARAP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP3→partner) and Y-score (partner→ARAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCN10A →	+0.129	+4.044	<.001	.003	3	2
CNS	C1orf146 →	+0.027	+4.044	<.001	.003	3	2
LARGE_INTESTINE	DPH1 →	+0.643	+2.502	.004	.005	3	2
LARGE_INTESTINE	NSUN4 →	+0.596	+2.502	.001	.005	3	2
OVARY	POLR2H →	+0.557	+3.243	.001	.003	3	2
LARGE_INTESTINE	GLOD4 →	+0.675	+3.714	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

SCN10A by ARAP3 expression — CNS

Explore this box plot interactively →