ARAP3

Across TCGA pan-cancer cohorts, ARAP3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ARAP3 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ARAP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARAP3 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

KIRP, MESO, and UVM are the cancer types where ARAP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.597	0.778	<.001	140	view →
MESO	OS	Median	All	0.269	0.506	<.001	83	view →
UVM	DFS	Median	All	0.773	0.470	.001	66	view →
LGG	DFS	Median	All	0.284	0.508	<.001	54	view →
KIRC	OS	Quartile	All	0.886	0.746	<.001	44	view →
CESC	DFS	Quartile	All	0.431	0.713	<.001	44	view →
ACC	DFS	Median	All	0.756	0.426	<.001	39	view →
SCLC	OS	Quartile	II,III,IV	0.225	0.640	.012	24	view →
COAD	OS	Quartile	II,III,IV	0.753	0.414	.002	24	view →
LUSC	DFS	Median	All	0.612	0.705	.007	24	view →
HNSC	OS	Median	All	0.611	0.792	.008	19	view →
PCPG	DFS	Tertile	All	1.000	0.791	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ARAP3–KIRP (DFS)

Open the KIRP breakdown →