AR

Across TCGA patient cohorts, AR mutation is significantly associated with the RNA expression of many other genes, with 3,456 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AR-associated genes across cancer lineages are DVL2, AUP1, and FLII. Each is linked with AR in more than 3 cancer types. Because this analysis shows association rather than direction, both AR-to-partner and partner-to-AR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DVL2 grouped by AR-low versus AR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AR→partner) and Y-score (partner→AR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DVL2 →	+0.324	+1.485	.004	.003	3	4
STAD	AUP1 →	+0.453	+3.338	<.001	.004	3	4
COAD	FLII →	+0.488	+3.040	<.001	<.001	3	3
UCEC	FCER1A →	-0.536	-1.647	.001	.001	3	3
COAD	POLR2A →	+0.634	+2.827	<.001	.001	3	3
UCEC	RPL17P50 →	+0.310	+1.947	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,456 associations by consensus.

DVL2 by AR expression — UCEC

Explore this box plot interactively →