AR

Across TCGA pan-cancer cohorts, AR RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated AR data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher AR RNA is associated with better overall survival. In most high-consensus cancer types, elevated AR expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, KIRP, and HNSC are the cancer types where AR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.747	0.514	<.001	200	view →
KIRP	DFS	Median	II,III,IV	0.819	0.523	<.001	64	view →
HNSC	DFS	Quartile	III,IV	0.670	0.426	.001	60	view →
ACC	DFS	Median	II,III,IV	0.580	0.281	.006	50	view →
BRCA	OS	Median	IV	0.783	0.301	.001	49	view →
LGG	OS	Median	All	0.368	0.529	<.001	49	view →
LIHC	OS	Median	III,IV	0.781	0.423	<.001	39	view →
UVM	DFS	Tertile	II,III,IV	0.308	0.631	.004	32	view →
STAD	OS	Tertile	All	0.517	0.682	.008	28	view →
SKCM	DFS	Quartile	All	0.783	0.563	.009	23	view →
SCLC	OS	Median	II,III,IV	0.426	0.706	.008	21	view →
UCS	DFS	Tertile	III,IV	0.538	0.111	.014	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

AR–KIRC (OS)

Open the KIRC breakdown →